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The irradiation was performed at nm. B and C, the sedimentation pattern of fibrils without B or with C laser irradiation. D, identification of chemical modifications by amino acid analysis. E—H, mass spectra.

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Click on the image to see a larger version. Selected References These references are in PubMed. This may not be the complete list of references from this article. Does nitric oxide mediate autoimmune destruction of beta-cells?

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This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. This article has been cited by other articles in PMC. Abstract Anal squamous cell cancer is an uncommon malignancy caused by infection with oncogenic strains of Human papilloma virus. Anal cancer is much more common in immunocompromised persons, including those infected with Human immunodeficiency virus.

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Next Section Abstract To understand the mechanism by which amyloid fibrils form, we have been making real-time observations of the growth of individual fibrils, using total internal fluorescence microscopy combined with an amyloid-specific fluorescence dye, thioflavin T ThT. Several pieces of evidence suggest that the excited ThT transfers energy to ground state molecular oxygen, producing active oxygen, which causes various types of chemical modifications. The results imply a novel strategy for preventing the deposition of amyloid fibrils and for destroying preformed amyloid deposits. Previous Section Next Section Amyloid fibrils are associated with the pathogenesis of more than 20 serious diseases, including Alzheimer, Parkinson, and Huntington diseases, and dialysis-related amyloidosis 1 , 2.

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